Program    

Thursday April 24
   
  Work shop 1.

09.30 – 12.30

 Astrid Fagreus Laboratory (AFL), Karolinska Institute.
Helene Fredlund
   

Welcome to a fascinating insight into one of Europe’s most modern and unique research facilities. The Astrid Fagraeus Laboratory is Scandinavia’s only laboratory housing primates and has recently become the first Swedish lab to achieve an AAALAC-accreditation. This tour will introduce you to our work with everything from mice to monkeys, as well as our ongoing research about infectious diseases, animal welfare and behavior studies and our experiences from GLP practices.
We’ll guide you around the facility, focusing on the areas that interest you most (please select your areas of interest when signing up) and we’ll do our best to answer all and every question you’ll have. You are very welcome to the AFL at Karolinska Institutet in Stockholm
Leased bus leaves from the Waterfront to the AFL

13.00 - 13.15 Opening ceremony
  Chairman Ann-Christine Eklöf
13.15 – 14.15 K.J. Öbrink Memorial lecture
From automata to conscious being 
Martin Ingvar, Karolinska Institutet, SE
14.15 – 15.00 Dog-to-human Comparative Genomics to identify genetic risk factors for cardiomyopathies
  Göran Andersson, Swedish Univ. of Agriculture Sciences, SE
15.00 – 15.30 Coffee-break in the exhibition area
Transgenic techniques
Chairman Thomas Blom
15.30 – 16.00 Transgenic techniques - an overview
Thomas Blom,University of Lund, SE
16.00 – 16.30 Rho GTPases - Advanced transgenic technologies
Cord Herbert Brakebusch, University of Copenhagen, DK
16.30 – 17.00 Experimental Epilepsy - Optogenetics
Merab Kokai, University of Lund, SE
17.00 – 17.30 Morphology / Pathology - Phenotyping
DVM Raul Kuyper, Karolinska Institutet,SE
17.30 – 18.00 Inflammation / genetics - Genetic Drift
Jan-Bas Prins, President, FELASA
     
18.15 Get together
     
 
 

Friday April 25
  3R, communication, education and ethical evaluations
  Chairman Mats Sjöquist
08.30 – 09.00 Bringing the directive 2010/63/ EU into the research facility – Will it improve life for the animals or the bureaucrats?
  Mats Sjöquist, Swedish center for Animal Welfare, SE
09.00 – 09.30 Animal experimentation in Switzerland: What do you need and how do you apply?
  Marcel Gyger, EPFL, Schweiz
09.30 – 10.00 A common European education & training framework - is mutual recognition achievable?
  David Smith, FELASA, UK
10.00 – 10.30 Coffee-break in the exhibition area
10.30 – 11.00 Ethics review of animal experiments in Europe under Directive 2010/63/EU
  Anna Olsson, Imbc, Univ. of Porto, P
11.00 – 11.30 LAS-E: a Swedish Consortium in Laboratory Animal Science
  Brun Ulfhake, Karolinska Institutet, SE
11.30 – 12.30 General discussion on differences in detail of regulation among nations
  Maggy Jennings, RSPCA, UK
12.30 – 13.30 Lunch and AGM
    Experimental Cardiovascular research
    Chairman Aavo Lang
13.30–14.15 Endovascular intervention meets multimodal imaging: studies on drug/cell delivery and ischemic stroke
Key note speaker Staffan Holmin, Karolinska University Hospital / KI, SE
14.15-14.45 Models for understanding and treatment of myocardial ischemia
John Pernow, Karolinska University Hospital / KI, SE
14.45 – 15.00 Animal Research: time to talk
 

Kirk Leech, Executive Director, European Animal Research Association (EARA)
15. 00– 15.30 Coffee-break in the exhibition area
    Refinement in experiment with high severity
    Chairman Klas Abelson
15-30 – 16.00 Alterations in spontaneous behavior as a readout for changes in pain thresholds
Camilla Svensson, Karolinska Institutet,SE
16.00 – 16.30 Chronic inflammatory disease models. Why? How? Relevance to human disease
Robert Harris, Karolinska Institutet, SE
16.30 – 17.00 Aminothiazoles decreases prostaglandin E2 in vitro and ameliorates experimental periodontitis in rats
Anna Kats,Department of Dental medicine, Karolinska Institutet, SE
17.00 – 18.00 Free communication / Poster presentation
     
18.00 -   Exhibitors evening
     
     

Friday April 25 Workshops
   
  Work shop 1.

13.30 – 16.30

Astrid Fagreus Laboratory (AFL), Karolinska Institute,
Helene Fredlund
    Welcome to a fascinating insight into one of Europe’s most modern and unique research facilities. The Astrid Fagraeus Laboratory is Scandinavia’s only laboratory housing primates and has recently become the first Swedish lab to achieve an AAALAC-accreditation. This tour will introduce you to our work with everything from mice to monkeys, as well as our ongoing research about infectious diseases, animal welfare and behavior studies and our experiences from GLP practices.
We’ll guide you around the facility, focusing on the areas that interest you most (please select your areas of interest when signing up) and we’ll do our best to answer all and every question you’ll have. You are very welcome to the AFL at Karolinska Institutet in Stockholm
Leased bus leaves from the Waterfront to the AFL
  Work shop 2.
(Participation without any advanced registration)
13.30 – 17.30 “Ethical evaluation” & “Fasting and restricted diet”
Helena Röcklinsberg, Mats Sjöquist and Karin Sandstedt
   

According to the new directive, the 3Rs shall be implemented in all research (Art 38). This is no easy task, neither from a practical perspective, nor from an ethical one. How do we ensure that this requirement has been fulfilled? To what extent ought scientists to contribute to the development of alternative methods in their field of research? Another crucial dimension of implementation of the 3R lies in the decision-making process regarding a research protocol. The workshop will elaborate on transparency, decision criteria and the debated role of empathy in ethical decisions. In order to situate these ethical dimensions in a relevant and concrete context we will give examples on animal research often challenging the animal ethics evaluation - with various outcomes when it comes to decision: fasting and restricted diet.

How can the 3Rs be implemented in research involving fasting? Based on what criteria can a high degree of severity be judged justified? How can such decisions be communicated with the public? We cordially invite all participants to contribute with their views and experience in an engaging discussion on an important and challenging theme.

13.30-13.35 Introduction
  Karin Sandstedt Karolinska Institutet, SE
13.35-14.00 Aspects from the researcher on fasting of laboratory animals  
  Lars Selander Karolinska Institutet, SE
14.00-14.30 Physiological aspects on fasting in rodents
  Dorte Bratbo Sörensen, DK
14.30-15.00 Fasting in rodents
  Adrian Smith, Norecopa, N
15.00-15.30 Coffee-break in the exhibition area
15.30-15.40 Invited response: Ethical evaluation of fasting
  Maggy Jennings, RSPCA, UK
15.40-16.00 Increased focus on 3R and ethical decision making
  Helena Röcklinsberg, Swedish Univ. of Agriculture, SE
16.00-16.30 Communication of ethical evaluation
  Tjard de Cook Buning Athena Institute, NL
16.30-17.30 Open discussion with all participants
  Mats Sjöquist Swedish center for Animal Welfare, SE
     
     
Saturday April 26
    Zebra fish and Aquatic animals
    Chairman Emma Ljunggren
08.45 -  09 .45 Fish and mammals - differences and similarities
Key note speaker Svante Winberg, Uppsala University, SE
09.45 - 10.15 Setting up a new zebrafish facility – experiences from the Linköping University facility
  Lasse Dahl Jensen, University of Linköping, SE
10.15 – 10.45 Coffee-break in the exhibition area
10.45 – 11.15 Switching gears in the zebrafish spinal locomotor circuits
  Jessica Ausborn,Karolinska Institutet, SE
11. 15 – 11.45 Regulation of angiogenesis by hypoxia and circadian rhythms and its importance in disease
  Lasse Dahl Jensen, University of Linköping, SE
11.45 - 12.15 Helping unravel secrets - Transgenics in the zebrafish
Emma Ljunggren, SE
12.15 - 12.30 Free communication
12.30 – 13.30 Lunch
  Behavioral studies in  different species
  Chairman Anders Forslid
13.30 – 14.15 Behavioral methods in experimental research An overview
  Brun Ulfhake, Karolinska Institutet, SE
14.15 – 14.45 Development of novel pharmacotherapies for alcohol dependence using validated animal models
Pia Stensland, Karolinska Institutet, SE
14.45 - 15.15 Behavioral research using other species than rodents
Mathias Oswath, University of Lund, SE
15.15 – 15.45 Coffee-break in the exhibition area
  Experimental Neurosurgery
  Chairman Ann-Christin Sandberg-Nordqvist
15.45 – 16.30 Spinal cord repair – challenges on the way to the patient ?
Per Mattsson, Karolinska University Hospital, SE
16.30 – 16.45 Refinement through enrichment for rodents with spinal cord injury
PhD student Arvid Frostell, Karolinska University Hospital,SE
16.45 – 17.15 Refined animal models in traumatic brain injury - a tool for the development of novel clinical treatments
Niklas Marklund, Uppsala University Hospital, SE
17.15 – 17.30 Free communication
   
19.00- Gala dinner
   
   
Saturday April 26 Workshops
  Workshop 3
09.00 -12.30 Evaluation of animal welfare.
Katarina Cvek, Birgitta Staaf Larsson and Patricia Hedenqvist
   

During this workshop assessment of animal welfare using different parameters (animal based parameters such as behavior and resource based parameters such as housing, handling or care) will be discussed. Videoclips and photographs showing animals in different situations that could affect the welfare of the animals (housing, care, procedures, disease models etc) will be shown. The participants on the workshop will then actively perform evaluations of the animal welfare or impaired welfare using an interactive audience response system. This system enables the participants to compare evaluations from the whole group and discuss the results together. The workshop is aimed for scientists, veterinarians and technicians. The participants will be awarded a certificate of attendance that will merit for CPD credits.

Room C4 Level 2 Workshop 4
13.30 – 17.30 Zebra fish as a research model.
In collaboration with Fondazione Guido Bernardini
    The workshop will contain topics about new technologies, advantages and disadvantages in zebra fish/aquatics
Experience from a veterinarian point of view, managing a zebrafish colony
Washing fish tanks in a professional manner
Zebrafish housing and husbandry
What does the Directive say about aquatics all from Zebra fish to Cephalopods
13.30 – 13.45   Introduction
   

Ann-Christine Eklöf, Fondazione Guido Bernardini 
13.45 – 14.00   What does the Directive say?
   

Swante Winberg, Uppsala University, SE
14.00 – 14.30   Zebrafish Housing and Husbandry
    Marco Brocca, Tecniplast Spa, Italy
14.30 – 15.15   Zebrafish biology and relative health management
    Viola Galligioni, Università di Trento, Italy
15.15 – 15.45   Coffee break in the exhibition area
15.45 – 16.30   Pure water or chemicals:
 Can (or should) industrial detergents play a role in zebrafish husbandry and hygiene management?
    Karin Finger-Baier, MPI Martinsried, Germany
16.30 –  

Discussion

Sunday April 27
    Animal welfare - Refinement
    Chairman Hanna-Marja Vopio
09.00 – 09.30 Research update on animal welfare and enrichment for laboratory rodents
Elin Spangenberg,Swedish Univ. of Agriculture, SE
09.30 – 10.00 Being single – a big deal? Solitary housing in common laboratory species
Karolina Westlund, Karolinska Institutet, SE
10.00 – 10.30 Coffee-break in the exhibition area
10.30 – 11.00 Ethological perspectives on laboratory non-human primate housing
Karolina Westlund, Karolinska Institutet, SE
11.00 – 11.30 Telemetri
Anders Arner Karolinska Institutet, SE

11.30 - 12.00 Rodent identification and animal welfare
Kristina Dahlborn, Swedish Univ. of Agriculture Science, SE
12.00 – 12. 30 Norecopa: using a national consensus-platform to promote the 3Rs
  Adrian Smith, Norecopa, N
12.30

Closing ceremony
Prices for best poster and best oral presentation
Presenting Scand-LAS 2015 annual meeting
Take away lunch
   

 

 Workshop 5
09.00 – 12. 00 Pain and Analgesia
Klas Abelson and Cathrine Juel Bundgaard
   

This workshop will focus on animal models subjected to painful procedures, where there is a known or suspected effect of analgesic treatment on the experimental data. The workshop consists of lectures and case studies in groups. The lectures will cover the theory of pain and analgesia; circumstances under which pain and/or analgesia may compromise the scientific objectives; and various examples of relevant models. The group work will focus on actual cases, where it will be discussed to what extent the pain or analgesia may have any impact on the experimental data, and how this best can be circumvented. The workshop is aimed for scientists, veterinarians and technicians. The participants will be awarded a certificate of attendance that will merit for CPD credits

This workshop is organized by Scand-LAS Working Group on Education and Professional Development

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   
   
 
 
    Updated: 2014-04-09 8:36    
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